The niacinamide concentration is typically 2mg/mL regardless of tirzepatide concentration, so the total niacinamide dose per injection increases proportionally with tirzepatide dose
Learning to recognize and respect these new, sometimes more subtle, signals of fullness is essential
For Wegovy, NICE guidance (TA875) recommends discontinuation if patients do not achieve at least 5% weight loss after 6 months at the maintenance dose, and NHS treatment is typically limited to a maximum of 2 years
27 Other side effects and risks of GLP-1s include: Dizziness Mild tachycardia (increased heart rate) Headaches Injection site reactions, such as itchiness and redness Hypoglycemia (low blood sugar) Severe Risks & Contraindications While less common, GLP-1s can pose severe risks such as intestinal blockage and gastroparesis 28 , which refer to the delay in gastric emptying without evidence of mechanical obstruction
GLP-1 agonists were originally approved to treat Type 2 Diabetes (T2D) but their most recent incarnations, which consist of both next generation GLP-1s and combinations (Ozempic, Mounjaro, Wegovy, Zepbound), have moved beyond the realm of T2D into the treatment of obesity